Prof. Dr. Meir
Diagnosis and Treatment of Premenstrual
Syndrome / Premenstrual Dysphoric Disorder
Prämenstruelles dysphorisches Syndrom.
The inclusion of research diagnostic criteria for premenstrual
dysphoric disorder (PMDD) in the DSM-IV recognises the fact that some women in their
reproductive years have extremely distressing emotional and behavioural symptoms
Prozent aller fruchtbaren Frauen leiden unter PMDD.
many as 75% of women experience some symptoms of premenstrual syndrome. However, only 3%
to 8% of women in this age group meet criteria for PMDD. These women report premenstrual
symptoms that seriously interfere with their lifestyle and relationships. The etiology of
PMDD is largely unknown, but the serotonergic system which is in close reciprocal
relationship with the gonadal hormones has been identified as the most plausible target
for interventions. Thus, the serotonin reuptake inhibitors (SSRIs) are emerging as
the most effective treatment option for this population.
ist die effektivste Therapie bei PMDD.
from several randomised placebo-controlled trials in women with PMDD, with predominantly
psychological symptoms of irritability, tension, dysphoria and lability of mood, have
clearly demonstrated that the SSRIs have excellent efficacy and minimal side
effects. More recently, several studies have indicated that intermittent (premenstrually
only) treatment with SSRIs is equally effective in these women and, thus, may offer
an attractive treatment option for a disorder that is itself intermittent.